Omega-3, CoQ10, magnesium and soluble fiber each have randomized-trial evidence behind them for cardiovascular health. Here is what the clinical literature actually shows on dosage, what the Q-Symbio and REDUCE-IT trials found, and how to combine the four safely.

Berberine has been used in traditional medicine for centuries, but the modern clinical evidence is what's interesting. A 2024 meta-analysis pooling 50 RCTs and 4,150 participants is the strongest look yet at what it actually does to blood sugar and lipids.